Fusion Antibodies is a CRO which offers a range of Antibody Engineering services. Some of our most popular antibody configurations are shown below but many more are possible. If you have an idea for an alternative antibody construct, contact us today and we would be happy to disucss!

• Chimeric Antibodies
• Reduce the immunogenicity of the antibody in vivo.
• Optional Antibody Sequencing service available
• scFv antibody fragments

There are many advantages in using scFv’s, particularly in the fields of therapeutics and diagnostics. scFv’s offer several advantages over monoclonal antibodies as carriers of radionuclei and drugs to tumors, including greater tumour penetration due their small size, low kidney uptake, rapid blood clearance and a lower negative response by the human immune system.

Fab and F(ab’)2 antibody fragments

Fab fragments differ from scFv’s as they contain both variable domains and constant regions thus their construction and ultimate expression is somewhat more complex. We have experience in antibody production. If a monoclonal antibody is available the fab fragment can be created enzymatically, or by first sequencing the variable domains followed by recombinant expression. It is also possible to create a fab fragment whenever there is no monoclonal antibody available simply from the antibody variable region sequences if known.