We have built up HAIL (Human Antibody Immune Library) technology to develop full human monoclonal antibodies. In this technology, instead of immunizing humans (which is ethically impossible), strong immune responses and high affinity antibodies are generated by immunizing humanized mice. After that, a phage display human antibody library is constructed to select high affinity antibodies against the immunogens. The resultant antibodies are fully human that experience affinity maturation in vivo.

This unique technology combines our “humanized” transgenic mice (FHAT mice) with our unparalleled expertise in phage display human antibody library technology.

Being one of the most important means for generating full human antibodies, hybridoma generation using humanized transgenic mice has become an extremely powerful tool for antibody drug discovery.